Hemifusomes: Biologists Discover Previously Unknown Organelle Complexes inside Human Cells

Jun 25, 2025 - 12:45
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Hemifusomes: Biologists Discover Previously Unknown Organelle Complexes inside Human Cells
Representative cryo-electron microscopy image of the leading edge of a RAT-1 cell cultured on cryo-EM grids. Lamellipodia and filopodia in the upper right corner delineate the cell border, separating the cytoplasm (Cyt) from the extracellular space (Ext). Vesicular organelles are highlighted in color: early endosome-like vesicles (En, pink), multivesicular bodies (MVB, blue), hemifusomes (HF, yellow), and flipped hemifusomes (fHF, green). Scale bar - 0.5 µm. Image credit: Tavakoli et al., doi: 10.1038/s41467-025-59887-9.

Hemifusomes constitute up to 10% of vesicular organelles at the cell periphery but do not engage in canonical endocytic pathways, according to a team of biologists from the University of Virginia and the National Institutes of Health.

The post Hemifusomes: Biologists Discover Previously Unknown Organelle Complexes inside Human Cells appeared first on Sci.News: Breaking Science News.

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